Tirrell Group

Anna Tropnikova

  • Undergraduate Researcher (Alumni)

Anna Tropnikova was born in Novokuznetsk, Russia, in 1993. She received the international baccalaureate diploma upon graduating high school and is currently an undergraduate at University of Chicago interested in pursuing a career in medicine. She is on the board for the Pre-Medical Students Association and works with the publicity committee for MEDLIFE. In April 2013, she joined Professor M. Tirrell’s group as a research assistant under Dimitris Priftis. After becoming familiar with the rheological properties of polypeptides undergoing complex coacervation, she moved on to investigating the rheology of other novel polymer-based soft materials.

She's currently exploring the ability of hydrogels to respond to stress and strain under differing salt and polymer concentrations, and to what extent this effect changes over a range of temperatures. Hydrogels are a relatively new material with vast potential for medicinal application and drug delivery (i.e. direct injection into the bloodstream with optimal and natural recovery). Hydrogels are meant to be liquid upon injection, only self-assembling and aiding in drug delivery once inside the body, and dissolving harmlessly thereafter. Anna hopes her work with synthetic soft materials will have a substantial long-term application in the clinical setting.

Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins

Yu Tian, Matthew V. Tirrell, James L. LaBelle. "Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins". Advanced Healthcare Materials, 2022.

Targeted polyelectrolyte complex micelles treat vascular complications in vivo

Zhengjie Zhou, Chih-Fan Yeh, Michael Mellas, Myung-Jin Oh, Jiayu Zhu, Jin Li, Ru-Ting Huang, Devin L Harrison, Tzu-Pin Shentu, David Wu, Michael Lueckheide, Lauryn Carver, Eun Ji Chung, Lorraine Leon, Kai-Chien Yang, Matthew V Tirrell, Yun Fang. "Targeted polyelectrolyte complex micelles treat vascular complications in vivo", PNAS.

Protein primary structure correlates with calcium oxalate stone matrix preference

Yu Tian, Matthew Tirrell, Carley Davis, Jeffrey A Wesson. "Protein primary structure correlates with calcium oxalate stone matrix preference". Plos One, 2021, e0257515.

Polyampholyte physics: Liquid–liquid phase separation and biological condensates

Dinic, Jelena, Amanda B. Marciel, and Matthew V. Tirrell. "Polyampholyte physics: Liquid–liquid phase separation and biological condensates." Current opinion in colloid & interface science 54 (2021): 101457.

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

"Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity". ACS Cent. Sci. 2021, 7, 8, 1368-1380.

Advances in the Structural Design of Polyelectrolyte Complex Micelles

Alexander E. Marras, Jeffrey M. Ting, Kaden C. Stevens, and Matthew V. Tirrell. "Advances in the Structural Design of Polyelectrolyte Complex Micelles". J. Phys. Chem. B, 2021, 125, 26, 7076-7089.

Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles

Alexander E. Marras, Trinity R. Campagna, Jeffrey R. Vieregg, and Matthew V. Tirrell. "Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles". Macromolecules, 2021, 54, 13, 6585-6594.

Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes

Lu Li, Artem M Rumyantsev, Samanvaya Srivastava, Siqi Meng, Juan J de Pablo, Matthew V Tirrell. "Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes", Macromolecules, 2020.

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