Tirrell Group

Bret Ulery, Ph.D.

  • Postdoctoral Scholar (Alumni 2014)
    Current: Faculty member, University of Missouri

  • Contact: bulery@uchicago.edu
    773.702.7063

Bret earned his BS in biochemistry and BSe in chemical engineering from the University of Iowa in 2006 and his PhD in chemical engineering with a graduate minor in immunobiology from Iowa State University in 2010. As an undergraduate, Bret conducted research in a number of laboratories in a variety of departments including biochemistry, radiology, mechanical engineering, and chemical engineering. As a senior, he worked with Professor Allan Guymon and Dr. Jason Clapper synthesizing biodegradable polymeric shunts to treat eye diseases, igniting a passion for biomaterials-based research. As a graduate student at Iowa State University, Bret worked for Professor Balaji Narasimhan creating polyanhydride nanoparticles for use as single-dose intranasal vaccine delivery vehicles. After earning his PhD, Bret spent two years as a postdoctoral fellow under the advisement of Professor Cato Laurencin at the University of Connecticut Health Center conducting localized anesthetic delivery and musculoskeletal regenerative engineering research.

Bret joined the Pritzker School of Molecular Engineering in 2012 as a postdoctoral scholar working with Professor Matthew Tirrell. His research focuses on the immunotherapy applications of peptide amphiphile micelle technology. Bret's long-term interests include the design of novel biomodulatory materials to improve health care technologies.

As the biomaterials community tackles grand challenges like intracellular drug delivery and complex tissue regeneration, minimalist strategies of the past that employ inert biomaterials serving a singular function are suboptimal. Instead novel, multi-dimensional strategies need to be developed in order to achieve the next series of breakthroughs in biomedical research. Bret's research focuses on the design and development of a new class of biomaterials termed biomodulatory materials whose physicochemical properties allow for them to directly modulate cell and host responses. Biomodulatory materials have the potential to impact a number of fields with Bret's personal interest focusing on immunoengineering, cancer therapy, and regenerative engineering. As a member of the Tirrell group, Bret specifically investigates the immunological and cancer therapy applications of peptide amphiphile micelles.

Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins

Yu Tian, Matthew V. Tirrell, James L. LaBelle. "Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins". Advanced Healthcare Materials, 2022.

Targeted polyelectrolyte complex micelles treat vascular complications in vivo

Zhengjie Zhou, Chih-Fan Yeh, Michael Mellas, Myung-Jin Oh, Jiayu Zhu, Jin Li, Ru-Ting Huang, Devin L Harrison, Tzu-Pin Shentu, David Wu, Michael Lueckheide, Lauryn Carver, Eun Ji Chung, Lorraine Leon, Kai-Chien Yang, Matthew V Tirrell, Yun Fang. "Targeted polyelectrolyte complex micelles treat vascular complications in vivo", PNAS.

Protein primary structure correlates with calcium oxalate stone matrix preference

Yu Tian, Matthew Tirrell, Carley Davis, Jeffrey A Wesson. "Protein primary structure correlates with calcium oxalate stone matrix preference". Plos One, 2021, e0257515.

Polyampholyte physics: Liquid–liquid phase separation and biological condensates

Dinic, Jelena, Amanda B. Marciel, and Matthew V. Tirrell. "Polyampholyte physics: Liquid–liquid phase separation and biological condensates." Current opinion in colloid & interface science 54 (2021): 101457.

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

"Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity". ACS Cent. Sci. 2021, 7, 8, 1368-1380.

Advances in the Structural Design of Polyelectrolyte Complex Micelles

Alexander E. Marras, Jeffrey M. Ting, Kaden C. Stevens, and Matthew V. Tirrell. "Advances in the Structural Design of Polyelectrolyte Complex Micelles". J. Phys. Chem. B, 2021, 125, 26, 7076-7089.

Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles

Alexander E. Marras, Trinity R. Campagna, Jeffrey R. Vieregg, and Matthew V. Tirrell. "Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles". Macromolecules, 2021, 54, 13, 6585-6594.

Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes

Lu Li, Artem M Rumyantsev, Samanvaya Srivastava, Siqi Meng, Juan J de Pablo, Matthew V Tirrell. "Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes", Macromolecules, 2020.

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