Whitney Fowler
Tirrell Group

Whitney Fowler

  • Ph.D. Candidate,
    NSF Graduate Research Fellow,
    Chicago Center for Teaching Fellow (Alumni 2022)
    Current: Faculty member, Harvey Mudd College

  • Contact: wcfowler@uchicago.edu
    773.702.7063
  • Office Location:
    5640 South Ellis Avenue
    Eckhardt Research Laboratory 108
    Chicago, IL 60637

Whitney Fowler received her BE in chemical and biomolecular engineering from Vanderbilt University in spring 2015. After working for a year for a nonprofit organization, she came to the University of Chicago to work toward her PhD at the Pritzker School of Molecular Engineering. She returned to academia wanting to do research directed toward real-world applications and problems, specifically that of the global clean water crisis. Under the coadvisement of Professor Matthew Tirrell and Professor Juan de Pablo, Whitney is currently working on designing materials to selectively isolate and recycle phosphate from aqueous solutions.

As many resources are being unsustainably depleted as the global population exponentially rises, society is turning toward wastewater as a new source for reclaiming valuable nutrients. One strategic resource to recover is phosphate. Though it is profuse in wastewater and agricultural runoffs, it is also a nonrenewable resource that is rapidly being depleted yet is vital for the food industry as a fertilizer. Thus, Whitney’s research aims to design, synthesize, and characterize a new class of materials that bind and retain phosphate and can subsequently release and recover it in a controllable manner. The platform for this material design is biologically inspired peptide amphiphiles (PAs), which can strategically incorporate the natural binding characteristics of proteins. Peptide binding sequences will be synthesized into the headgroup of PA molecules, which will then be displayed to the environment as the PAs spontaneously self-assemble into micelles and designable hydrogels. This work will not only explore fundamental knowledge of binding to functional groups on supramolecular structures, but also pave the way for developing an innovative class of capture-and-release materials that can target and reclaim valuable resources from water.

Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins

Yu Tian, Matthew V. Tirrell, James L. LaBelle. "Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins". Advanced Healthcare Materials, 2022.

Targeted polyelectrolyte complex micelles treat vascular complications in vivo

Zhengjie Zhou, Chih-Fan Yeh, Michael Mellas, Myung-Jin Oh, Jiayu Zhu, Jin Li, Ru-Ting Huang, Devin L Harrison, Tzu-Pin Shentu, David Wu, Michael Lueckheide, Lauryn Carver, Eun Ji Chung, Lorraine Leon, Kai-Chien Yang, Matthew V Tirrell, Yun Fang. "Targeted polyelectrolyte complex micelles treat vascular complications in vivo", PNAS.

Protein primary structure correlates with calcium oxalate stone matrix preference

Yu Tian, Matthew Tirrell, Carley Davis, Jeffrey A Wesson. "Protein primary structure correlates with calcium oxalate stone matrix preference". Plos One, 2021, e0257515.

Polyampholyte physics: Liquid–liquid phase separation and biological condensates

Dinic, Jelena, Amanda B. Marciel, and Matthew V. Tirrell. "Polyampholyte physics: Liquid–liquid phase separation and biological condensates." Current opinion in colloid & interface science 54 (2021): 101457.

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

"Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity". ACS Cent. Sci. 2021, 7, 8, 1368-1380.

Advances in the Structural Design of Polyelectrolyte Complex Micelles

Alexander E. Marras, Jeffrey M. Ting, Kaden C. Stevens, and Matthew V. Tirrell. "Advances in the Structural Design of Polyelectrolyte Complex Micelles". J. Phys. Chem. B, 2021, 125, 26, 7076-7089.

Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles

Alexander E. Marras, Trinity R. Campagna, Jeffrey R. Vieregg, and Matthew V. Tirrell. "Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles". Macromolecules, 2021, 54, 13, 6585-6594.

Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes

Lu Li, Artem M Rumyantsev, Samanvaya Srivastava, Siqi Meng, Juan J de Pablo, Matthew V Tirrell. "Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes", Macromolecules, 2020.

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