Zhengjie received his BS in pharmacy from Lanzhou University in 2013 and a PhD in biochemistry and molecular biology from East China Normal University in June 2018. In July 2018, he came to the US as a postdoctoral fellow at the University of Oklahoma, where he carried on noninvasive biomarker detection using phage and DNA origami. He also carried on the research about circRNA delivery for cancer therapy. He now is a postdoc scholar co-mentored by Dr. Fang and Dr. Tirrell at the University of Chicago. His research mainly focuses on biomaterials, nano-based drug/gene delivery, nanobiotechnology for cancer therapy, noninvasive biomarker detection, and vascular disease treatment. His current goal is to develop novel targeted nano-carriers that deliver constructs for CRISPR activation to inflamed endothelial cells. He aims to solve the increasing health risk by integrating cutting-edge technology, new concepts, and strategies with nanobiomaterials. His multidisciplinary training will allow him to contribute to this research.
Ion Specificity Influences on the Structure of Zwitterionic Brushes
Macromolecules 2023, 56, 5, 1945–1953
Sequence-Controlled Secondary Structures and Stimuli Responsiveness of Bioinspired Polyampholytes
Biomacromolecules 2022, 23, 9, 3798–3809
Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins
Yu Tian, Matthew V. Tirrell, James L. LaBelle. "Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides and proteins". Advanced Healthcare Materials, 2022.
Targeted polyelectrolyte complex micelles treat vascular complications in vivo
Zhengjie Zhou, Chih-Fan Yeh, Michael Mellas, Myung-Jin Oh, Jiayu Zhu, Jin Li, Ru-Ting Huang, Devin L Harrison, Tzu-Pin Shentu, David Wu, Michael Lueckheide, Lauryn Carver, Eun Ji Chung, Lorraine Leon, Kai-Chien Yang, Matthew V Tirrell, Yun Fang. "Targeted polyelectrolyte complex micelles treat vascular complications in vivo", PNAS.
Protein primary structure correlates with calcium oxalate stone matrix preference
Yu Tian, Matthew Tirrell, Carley Davis, Jeffrey A Wesson. "Protein primary structure correlates with calcium oxalate stone matrix preference". Plos One, 2021, e0257515.
Polyampholyte physics: Liquid–liquid phase separation and biological condensates
Dinic, Jelena, Amanda B. Marciel, and Matthew V. Tirrell. "Polyampholyte physics: Liquid–liquid phase separation and biological condensates." Current opinion in colloid & interface science 54 (2021): 101457.
Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity
"Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity". ACS Cent. Sci. 2021, 7, 8, 1368-1380.
Advances in the Structural Design of Polyelectrolyte Complex Micelles
Alexander E. Marras, Jeffrey M. Ting, Kaden C. Stevens, and Matthew V. Tirrell. "Advances in the Structural Design of Polyelectrolyte Complex Micelles". J. Phys. Chem. B, 2021, 125, 26, 7076-7089.
Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles
Alexander E. Marras, Trinity R. Campagna, Jeffrey R. Vieregg, and Matthew V. Tirrell. "Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles". Macromolecules, 2021, 54, 13, 6585-6594.
Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes
Lu Li, Artem M Rumyantsev, Samanvaya Srivastava, Siqi Meng, Juan J de Pablo, Matthew V Tirrell. "Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes", Macromolecules, 2020.