Jun Huang

Associate Professor of Molecular Engineering and Chair of the Admissions Committee in the UChicago Pritzker School of Molecular Engineering

Research Topics

Immunoengineering and Bioengineering

Research and Scholarly Interests

T Cell Immunology

mRNA Nanotechnology

T Cell Receptor

Chimeric Antigen Receptor

Immunotherapy

Research Groups

Huang Lab

Websites

Huang Lab

Office Location

Eckhardt Research Center
Room 371
5640 South Ellis Avenue
Chicago, IL 60637

Contact

773.702.3218

Email

huangjun@uchicago.edu

Jun Huang received his MS in chemical engineering and PhD in bioengineering at the Georgia Institute of Technology. He did his postdoctoral research in immunology at Stanford University.

Huang started his academic career as a faculty member in molecular engineering at the University of Chicago in 2015. He is a recipient of the American Cancer Society Scholar Award, Lynn Sage Research Award, NIH New Innovator Award, NSF Career Award, the Cancer Research Foundation Young Investigator Award, CBC Catalyst Award, and the NIH Pathway to Independence Award.

Description of Research

The Huang laboratory studies human immunology and immunotherapy at the single-cell level, with foci in T cell recognition and differentiation.

Huang Lab develops mRNA-based immunotherapies and adoptive cell therapies for human cancer, infectious diseases, and autoimmune disorders.

Publications

Stable, small, specific, low-valency quantum dots for single-molecule imaging

Jungmin Lee, Xinyi Feng, Ou Chen, Moungi G Bawendi, Jun Huang

Jungmin Lee, Xinyi Feng, Ou Chen, Moungi G Bawendi, Jun Huang. Stable, small, specific, low-valency quantum dots for single-molecule imaging. Nanoscale. 2018. Vol. 10.

Nanoscale

2018

Vol. 10

CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy

Jillian Rosenberg, Jun Huang

Jillian Rosenberg, Jun Huang. CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy. Current Opinion in Chemical Engineering. 2018. Vol. 19, Pg. 9-20.

Current Opinion in Chemical Engineering

2018

Vol. 19, Pg. 9-20

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

Ben S. Wendel, Daniel Del Alcazar, Chenfeng He, Perla M. Del Río-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su. The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes. Science Immunology. 2018.

Science Immunology

2018

A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflam.

Jiawei Guo, Hui Tao, Yin Dou, Lanlan Li, Xiaoqiu Xu, Qixiong Zhang, Juan Cheng, Songling Han, Jun Huang, Xiaodong Li, Xiaohui Li, Jianxiang Zhang

Jiawei Guo, Hui Tao, Yin Dou, Lanlan Li, Xiaoqiu Xu, Qixiong Zhang, Juan Cheng, Songling Han, Jun Huang, Xiaodong Li, Xiaohui Li, Jianxiang Zhang. A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflam.. Materials Today. 2017. Vol. 20, Pg. 493-500.

Materials Today

2017

Vol. 20, Pg. 493-500

Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Pep

Handan Acar, Ravand Samaeekia, Mathew R Schnorenberg, Dibyendu K Sasmal, Jun Huang, Matthew V Tirrell, James L LaBelle

Handan Acar, Ravand Samaeekia, Mathew R Schnorenberg, Dibyendu K Sasmal, Jun Huang, Matthew V Tirrell, James L LaBelle. Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Pep. Bioconjugate chemistry. 2017. Vol. 28, Pg. 2316-2326.

Bioconjugate chemistry

2017

Vol. 28, Pg. 2316-2326

T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Enfu Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J Taylor, Heidi A Wallweber, Dibyendu K Sasmal, Jun Huang, Jeong M Kim, Ira Mellman, Ronald D Vale

Enfu Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J Taylor, Heidi A Wallweber, Dibyendu K Sasmal, Jun Huang, Jeong M Kim, Ira Mellman, Ronald D Vale. T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition. Science. 2017.

Science

2017

Single-molecule fluorescence resonance energy transfer in molecular biology

Dibyendu K Sasmal, Laura E Pulido, Shan Kasal, Jun Huang

Dibyendu K Sasmal, Laura E Pulido, Shan Kasal, Jun Huang. Single-molecule fluorescence resonance energy transfer in molecular biology. Nanoscale. 2016. Vol. 8, Pg. 19928-19944.

Nanoscale

2016

Vol. 8, Pg. 19928-19944

Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer

J. Huang, X. Zeng, N. Sigal, P. J. Lund, L.F. Su, H. Huang, Chien, S. and M. M. Davis

J. Huang, X. Zeng, N. Sigal, P. J. Lund, L.F. Su, H. Huang, Chien, S. and M. M. Davis. Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer. Proceedings of the National Academy of Sciences. 2016.

Proceedings of the National Academy of Sciences

2016

Gamma delta T cells recognize haptens and mount a hapten-specific response

Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien

Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien. Gamma delta T cells recognize haptens and mount a hapten-specific response. Elife. 2014. Vol. 3, Pg. e03609.

Elife

2014

Vol. 3, Pg. e03609

Insights from in situ analysis of TCR–pMHC recognition: response of an interaction network

Cheng Zhu, Ning Jiang, Jun Huang, Veronika I Zarnitsyna, Brian D Evavold

Cheng Zhu, Ning Jiang, Jun Huang, Veronika I Zarnitsyna, Brian D Evavold. Insights from in situ analysis of TCR–pMHC recognition: response of an interaction network. Immunological reviews. 2013. Vol. 251, Pg. 49-64.

Immunological reviews

2013

Vol. 251, Pg. 49-64

A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+

J. Huang, M. Brameshuber, X. Zeng, J. Xie, Q. Li, Y. Chien, S. Valitutti, and M.M. Davis

J. Huang, M. Brameshuber, X. Zeng, J. Xie, Q. Li, Y. Chien, S. Valitutti, and M.M. Davis. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+. Immunity. 2013. Vol. 39, Pg. 836-857.

Immunity

2013

Vol. 39, Pg. 836-857

T cell antigen recognition at the cell membrane

Jun Huang, Christina Meyer, Cheng Zhu

Jun Huang, Christina Meyer, Cheng Zhu. T cell antigen recognition at the cell membrane. Molecular immunology. 2012. Vol. 52, Pg. 155-164.

Molecular immunology

2012

Vol. 52, Pg. 155-164

γδ T cells recognize common B cell antigens to initiate IL-17 response

X. Zeng, Y. Wei, J. Huang, E.W. Newell, B.A. Kidd, M.S. Kuhns, C.T. Weaver, M.M. Davis, and Y. Chien

X. Zeng, Y. Wei, J. Huang, E.W. Newell, B.A. Kidd, M.S. Kuhns, C.T. Weaver, M.M. Davis, and Y. Chien. γδ T cells recognize common B cell antigens to initiate IL-17 response. Immunity. 2012. Vol. 37, Pg. 524-534.

Immunity

2012

Vol. 37, Pg. 524-534

Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'prefe

J. Xie, J.B. Huppa, E.W. Newell, J. Huang, P.J. Ebert, Q.J. Li, and M.M. Davis

J. Xie, J.B. Huppa, E.W. Newell, J. Huang, P.J. Ebert, Q.J. Li, and M.M. Davis. Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'prefe. Nature Immunology. 2012. Vol. 13, Pg. 674-680.

Nature Immunology

2012

Vol. 13, Pg. 674-680

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+ T

Joseph J Sabatino, Jun Huang, Cheng Zhu, Brian D Evavold

Joseph J Sabatino, Jun Huang, Cheng Zhu, Brian D Evavold. High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+ T. Journal of Experimental Medicine. 2011. Vol. 208, Pg. 81-90.

Journal of Experimental Medicine

2011

Vol. 208, Pg. 81-90

Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular inte

N. Jiang*, J. Huang*, L.J. Edwards, B. Liu, Y. Zhang, C.D. Beal, B.D. Evavold, and C. Zhu

N. Jiang*, J. Huang*, L.J. Edwards, B. Liu, Y. Zhang, C.D. Beal, B.D. Evavold, and C. Zhu. Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular inte. Immunity. 2011. Vol. 34, Pg. 13-23.

Immunity

2011

Vol. 34, Pg. 13-23

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

J. Huang, V.I. Zarnitsyna, B. Liu, L.J. Edwards, N. Jiang, B.D Evavold, and C. Zhu

J. Huang, V.I. Zarnitsyna, B. Liu, L.J. Edwards, N. Jiang, B.D Evavold, and C. Zhu. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.. Nature. 2010. Vol. 464, Pg. 932-936.

Nature

2010

Vol. 464, Pg. 932-936

Measuring receptor–ligand binding kinetics on cell surfaces: from adhesion frequency to thermal fluc

Wei Chen, Veronika I Zarnitsyna, Krishna K Sarangapani, Jun Huang, Cheng Zhu

Wei Chen, Veronika I Zarnitsyna, Krishna K Sarangapani, Jun Huang, Cheng Zhu. Measuring receptor–ligand binding kinetics on cell surfaces: from adhesion frequency to thermal fluc. Cellular and molecular bioengineering. 2008. Vol. 1, Pg. 276.

Cellular and molecular bioengineering

2008

Vol. 1, Pg. 276

Kinetics of MHC-CD8 interaction at the T cell membrane

Jun Huang, Lindsay J Edwards, Brian D Evavold, Cheng Zhu

Jun Huang, Lindsay J Edwards, Brian D Evavold, Cheng Zhu. Kinetics of MHC-CD8 interaction at the T cell membrane. The Journal of Immunology. 2007. Vol. 179, Pg. 7653-7662.

The Journal of Immunology

2007

Vol. 179, Pg. 7653-7662

Memory in receptor–ligand-mediated cell adhesion

Veronika I Zarnitsyna, Jun Huang, Fang Zhang, Yuan-Hung Chien, Deborah Leckband, Cheng Zhu

Veronika I Zarnitsyna, Jun Huang, Fang Zhang, Yuan-Hung Chien, Deborah Leckband, Cheng Zhu. Memory in receptor–ligand-mediated cell adhesion. Proceedings of the National Academy of Sciences. 2007. Vol. 104, Pg. 18037-18042.

Proceedings of the National Academy of Sciences

2007

Vol. 104, Pg. 18037-18042

Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand bindi

Jun Huang, Juan Chen, Scott E Chesla, Tadayuki Yago, Padmaja Mehta, Rodger P McEver, Cheng Zhu, Mian Long

Jun Huang, Juan Chen, Scott E Chesla, Tadayuki Yago, Padmaja Mehta, Rodger P McEver, Cheng Zhu, Mian Long. Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand bindi. Journal of Biological Chemistry. 2004.

Journal of Biological Chemistry

2004

A Micropipet Aspiration System to Measure the Kinetics of Selectin/Ligand Interactions

Jun Huang, Juan Chen, Mian Long, Cheng Zhu

Jun Huang, Juan Chen, Mian Long, Cheng Zhu. A Micropipet Aspiration System to Measure the Kinetics of Selectin/Ligand Interactions. International Journal of Nonlinear Sciences and Numerical Simulation. 2002. Vol. 3, Pg. 199-202.

International Journal of Nonlinear Sciences and Numerical Simulation

2002

Vol. 3, Pg. 199-202

Kinetics of molecular interactions across the T cell–APC junction.

Veronika I Zarnitsyna, Ning Jiang, Jun Huang, Baoyu Liu, Lindsay Edwards, Brian Evavold, Cheng Zhu

Veronika I Zarnitsyna, Ning Jiang, Jun Huang, Baoyu Liu, Lindsay Edwards, Brian Evavold, Cheng Zhu. Kinetics of molecular interactions across the T cell–APC junction..

2002

Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells

Yunlong Zhao, Devin L. Harrison, Yuran Song, Jie Ji, Jun Huang, Enfu Hui

Yunlong Zhao, Devin L. Harrison, Yuran Song, Jie Ji, Jun Huang, Enfu Hui. Publications. Cell Reports. 2018. Vol. 24, Pg. p379–390.e6.

Cell Reports

Vol. 24, Pg. p379–390.e6